Two Independent Research Groups Are Studying the Effect of a New

question 354

Multiple Choice

Two independent research groups are studying the effect of a new anticoagulant on the incidence of deep-vein thrombosis after hip replacement surgery.  The first group designs a 1:1 randomized trial with 1000 patients comparing the new drug with the standard of care (500 patients in each group) .  The second group designs a similar randomized trial but intends to recruit 500 patients (250 patients in each group) .  Assuming similar populations for patient recruitment, the small study has a higher chance of which of the following?

• A)Early termination
• B)Outcome misclassification
• C)Selection bias
• D)Type I error
• E)Type II error

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Definitions:

Fall of Constantinople

The capture of the capital of the Byzantine Empire by the Ottoman Empire on May 29, 1453, an event that marked the end of medieval Byzantium.

Europeans

People originating from or native to the continent of Europe.

Confederation of States

A union of states or regions that come together for a common purpose, maintaining a degree of autonomy but governed by a central authority.

Nineteenth Century

The era spanning from January 1, 1801, to December 31, 1900, marked by profound industrial, cultural, and political shifts globally.