A 62-Year-Old Man with a History of Dyslipidemia and Type

question 595

Multiple Choice

A 62-year-old man with a history of dyslipidemia and type 2 diabetes mellitus comes to the emergency department due to severe substernal chest pain and diaphoresis that began 2 hours ago.  His ECG shows ST- segment elevation in leads V1 to V4.  He is taken to the cardiac catheterization lab and a complete occlusion of the mid-left anterior descending artery (LAD) is diagnosed.  A drug-eluting stent is placed in the LAD with complete restoration of flow, and the patient is started on aspirin and clopidogrel.  On the third day of hospitalization, the option of adding rivaroxaban is discussed with the patient.  He asks about the benefits and risks of the added therapy.  Based on the research abstract, which of the following measures would best reflect the net clinical benefit of rivoraxaban?

• A)"Death from any cause/myocardial infarction/stroke" and "intracranial hemorrhage"
• B)"Death from cardiovascular causes" and "fatal bleeding"
• C)"Death from myocardial infarction" and "TIMI bleeding requiring medical attention"
• D)"Intracranial hemorrhage" and "fatal bleeding"
• E)"Primary efficacy endpoint" only

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Definitions:

Random Variable

A variable whose possible values are outcomes of a random phenomenon, often denoted in probability and statistics.

Uncountable Number

A type of set or quantity of mathematical entities that cannot be paired with the natural numbers, indicating an infinite quantity that is not countably infinite.

Random Variable

A numerical variable that reflects the outcomes of an unpredictable event.

Standard Normal Distribution

A normal distribution with a mean of 0 and a standard deviation of 1, used in statistical analysis.