A Cohort of Patients with Myotonic Dystrophy Was Retrospectively Analyzed

question 337

Multiple Choice

A cohort of patients with myotonic dystrophy was retrospectively analyzed from 1993 to 2010 to identify incident cases of cancer.  The researchers identified 2 cases of thyroid cancer and reported a standardized incidence ratio of 7.4 (P-value = 0.02) .  This ratio was derived using which of the following formulas?

• A)Expected number of cases divided by the population at risk
• B)Observed incidence of cancer minus expected incidence of cancer
• C)Observed number of cases divided by expected number of cases
• D)Observed number of cases divided by population at risk
• E)Observed number of cases plus projected number of cases

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Definitions:

Directors

Individuals appointed or elected to oversee the management and make strategic and policy decisions for a corporation or organization.

Key Management Personnel

Individuals who have authority and responsibility for planning, directing, and controlling the activities of an entity, typically including the company’s directors and senior executives.

Significant Influence

The power to participate in the financial and operating policy decisions of an entity but is not control or joint control over those policies.

Subsidiary

A company that is controlled by another company, usually referred to as the parent company or holding company.