A Large Randomized Double-Blinded Study Compares a New Inhalational Steroid

question 8

Multiple Choice

A large randomized double-blinded study compares a new inhalational steroid agent to fluticasone in patients with moderate persistent asthma.  The following results are highlighted in the study: The investigators conclude that the study drug is more effective in this patient population.  Which of the following is the major limitation of this conclusion?

• A)Clinical significance
• B)Lack of power
• C)Lead-time bias
• D)Surrogate endpoint
• E)Type 1 error

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Definitions:

Profitability Index

A calculation used to determine the relative profitability of a project by dividing the present value of future cash flows by the initial investment.

Working Capital

Working capital is the difference between a company's current assets and current liabilities, indicating the liquidity and operational efficiency of the business.

Salvage Recovered

The estimated value or amount that can be recovered from an asset at the end of its useful life through sale or recycling.

Investment Required

The amount of capital needed to undertake a specific project, purchase assets, or start a business.