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A 55-Year-Old Man Comes to the Emergency Department Due to 4

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A 55-year-old man comes to the emergency department due to 4 days of worsening fever, cough, and chest pain.  The cough is productive of yellow sputum and occasionally streaked with blood.  The patient underwent allogeneic hematopoietic stem cell transplantation 6 weeks ago due to aplastic anemia.  His recovery was complicated by acute graft-versus-host disease, which is improving with high-dose corticosteroids and modification of immunosuppressive therapy.  He has also had prolonged neutropenia and is receiving infection prophylaxis with valganciclovir, fluconazole, trimethoprim-sulfamethoxazole, and levofloxacin.  The patient has no other medical problems and does not use tobacco, alcohol, or illicit drugs.  Temperature is 38.6 C (101.5 F) , blood pressure is 115/70 mm Hg, pulse is 105/min, and respirations are 22/min.  Pulse oximetry is 91% on ambient air.  Physical examination is notable for left lung crackles.  Laboratory testing shows a leukocyte count of 1,500/mm3 with 10% neutrophils.  Chest x-ray reveals an infiltrate in the left upper lobe, and subsequent CT scan of the chest shows a cavitary nodule with surrounding ground-glass opacities in the left upper lobe.  Which of the following is the most likely cause of this patient's current lung condition?

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Definitions:

Stressful Day

A day filled with high levels of stress, often due to challenging or overwhelming situations.

Bipolar Disorder

A mental disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks.

Depression

A psychiatric condition marked by a persistent feeling of sadness, lack of interest, and can lead to a variety of emotional and physical problems.

Mania

A mental state characterized by excessive excitement, energy, and euphoria, often seen in bipolar disorder.

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