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A Study Was Conducted to Assess the Relationship Between the Use

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A study was conducted to assess the relationship between the use of an over-the-counter pain reliever during pregnancy and the development of a neural tube defect in the offspring.  Mothers whose children have neural tube defects, as well as age-matched controls (mothers whose children do not have such abnormalities) , were interviewed using a standard questionnaire.  The study showed that the use of the pain reliever during pregnancy increases the odds of a neural tube defect, even after adjusting for race, other medication use, comorbidities, family history of congenital abnormalities, and serum folate levels.  The odds ratio is 1.5 (p = 0.03) .  Which of the following should be the major concern when interpreting the results of this study?


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