A Large Randomized Double-Blinded Study Compares a New Inhalational Steroid

question 8

Multiple Choice

A large randomized double-blinded study compares a new inhalational steroid agent to fluticasone in patients with moderate persistent asthma.  The following results are highlighted in the study: The investigators conclude that the study drug is more effective in this patient population.  Which of the following is the major limitation of this conclusion?

• A)Clinical significance
• B)Lack of power
• C)Lead-time bias
• D)Surrogate endpoint
• E)Type 1 error

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Definitions:

Peritubular Capillaries

Tiny blood vessels that surround the tubules in the kidney, involved in the exchange of substances between blood and the tubular fluid.

Glomerulus

A network of capillaries located in the nephrons of the kidney that plays a crucial role in filtering blood to form urine.

Grasshoppers

Insects of the suborder Caelifera within the order Orthoptera, known for their powerful hind legs for jumping.