A 65-Year-Old Woman Is Enrolled in a Clinical Trial to Test

question 73

Multiple Choice

A 65-year-old woman is enrolled in a clinical trial to test a new medication for rheumatoid arthritis.  The patient's condition has been poorly controlled despite prolonged treatment with multiple disease-modifying antirheumatic drugs.  The new medication is a CTLA4-Ig fusion protein that prevents CD28 from binding to CD80/86 on antigen-presenting cells.  A month after treatment begins, the patient reports a significant reduction in joint pain and stiffness.  Laboratory results reveal reduced levels of C-reactive protein and IL-2.  Which of the following is the most likely underlying cause of this patient's treatment response?

• A)Complement inhibition
• B)Immune complex clearance
• C)Negative selection
• D)Peripheral tolerance
• E)Sensitization

Apply Robert Gagné’s nine events of instruction to training delivery.

Understand various common training delivery problems and identify potential solutions for them.

Define an event of instruction and explain Gagne's nine events of instruction.

Explain the concept of trainability tests and their utility in employee training processes.

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Definitions:

Online

Connected to or available through the Internet or other digital network infrastructure.

Social Networking

The use of internet-based social media platforms to stay connected with friends, family, or colleagues, and to share information and ideas.

Territory

A defined geographical area that is claimed or occupied by a person, group, organization, or country, often associated with ownership, jurisdiction, and control.

Behavior Setting

A theory in ecological psychology that suggests an environment's physical and social settings influence the behavior of individuals within it.