A Brand-New Class of Aminoglycoside Antibiotic with an Elimination Half-Life

question 201

Multiple Choice

A brand-new class of aminoglycoside antibiotic with an elimination half-life of four hours is designed for intravenous administration. A clinical experiment compares two distinct dosage schedules: a lower dose administered three times per day and a greater dose administered once per day. In both regimens, the total daily dose per kilogram of body weight (mg/kg/day) is the same. The graph below shows the monitoring of serum medication levels in both groups: (extended interval) dosing, Green: multiple-daily dosing, MIC: minimum inhibitory concentration] It is found that both regimens are effective against gram-negative pathogens, with clinical improvement occurring slightly earlier on average with once-daily dosing.  Which of the following best explains the efficacy of once-daily dosing despite the short half-life of this antibiotic?

• A)Concentration-dependent killing
• B)High therapeutic index
• C)Linear dose-response relationship
• D)Low threshold dose
• E)Time-dependent killing

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