An Endocrainologist Is Trying to Study the Pathophysiology of Insulin

question 310

Multiple Choice

An endocrainologist is trying to study the pathophysiology of insulin production. If he detects a mutation in the insulin gene. And this results in a single amino acid substitution in the proinsulin molecule. The endocrainologist concluds that the amino acid substitution affects a segment of proinsulin removed during post-translational processing of the protein.  The polypeptide segment containing the mutation is most likely to undergo which of the following processes within pancreatic beta cells?

• A)Degradation in lysosomes
• B)Degradation in proteasomes
• C)Degradation in the rough endoplasmic reticulum
• D)Direct translocation across the plasma membrane
• E)Storage in secretory granules