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A 66-Year-Old Woman Comes to the Physician for a Routine

question 45

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A 66-year-old woman comes to the physician for a routine health maintenance examination. She feels well but is unhappy about being overweight. She has tried to lose weight for several years without success. She goes for a walk 3 times a week but she has difficulty following a low-calorie diet. She has type 2 diabetes mellitus and osteoarthritis. Her only current medication is metformin. She has never smoked. She is 160 cm (5 ft 3 in) tall and weighs 100 kg (220 lb) ; BMI is 39 kg/m2. Vital signs are within normal limits. Hyperpigmentation in skinfolds is noted at the neck as shown in the image below. A 66-year-old woman comes to the physician for a routine health maintenance examination. She feels well but is unhappy about being overweight. She has tried to lose weight for several years without success. She goes for a walk 3 times a week but she has difficulty following a low-calorie diet. She has type 2 diabetes mellitus and osteoarthritis. Her only current medication is metformin. She has never smoked. She is 160 cm (5 ft 3 in)  tall and weighs 100 kg (220 lb) ; BMI is 39 kg/m2. Vital signs are within normal limits. Hyperpigmentation in skinfolds is noted at the neck as shown in the image below.   Serum studies show an HbA1c of 9.5%, and a fasting serum glucose concentration of 158 mg/dL. Elevated serum levels of which of the following substances are most likely contributing to this patient's disease process? A) Beta-hydroxybutyrate B) C-peptide C) Free fatty acids D) High-density lipoprotein E) Low-density lipoprotein Serum studies show an HbA1c of 9.5%, and a fasting serum glucose concentration of 158 mg/dL. Elevated serum levels of which of the following substances are most likely contributing to this patient's disease process?

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