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A 66-year-old woman comes to the physician for a routine health maintenance examination. She feels well but is unhappy about being overweight. She has tried to lose weight for several years without success. She goes for a walk 3 times a week but she has difficulty following a low-calorie diet. She has type 2 diabetes mellitus and osteoarthritis. Her only current medication is metformin. She has never smoked. She is 160 cm (5 ft 3 in) tall and weighs 100 kg (220 lb) ; BMI is 39 kg/m2. Vital signs are within normal limits. Hyperpigmentation in skinfolds is noted at the neck as shown in the image below. Serum studies show an HbA1c of 9.5%, and a fasting serum glucose concentration of 158 mg/dL. Elevated serum levels of which of the following substances are most likely contributing to this patient's disease process?
Skills
Developed abilities or expertise in specific activities, often acquired through practice and learning, that enable proficient performance.
Jobs
Jobs consist of assigned tasks or roles performed by individuals within an organization or professional context in exchange for compensation.
Work Revolution
A period or movement where significant changes occur in the nature of work due to technological advances, economic shifts, or cultural transformations.
Work Relations
The dynamics and interactions between employers and employees, including negotiations, conflicts, and cooperation within a workplace.
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