Discuss Genetic Factors That Increase the Risk of Developing Colon

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The Answer is Investigations of multi-generational kindreds have identified hereditary forms of colorectal cancer. Hereditary nonpolyposis colorectal cancer (HNPCC) was later named the "Lynch Syndrome" after Henry T. Lynch, MD, who documented two large kindreds with this autosomal dominant syndrome. The cause of HNPCC is an inherited (germline) mutation in at least one of a set of genes that normally repair DNA, the mismatch repair genes. The Lynch Syndrome accounts for a small percentage of all colorectal cancer cases, perhaps 1-3%.
Familial Adenomatous Polyposis (FAP) or Gardner's syndrome is caused by a rare autosomal dominant germline HYPERLINK "http://en.wikipedia.org/wiki/Mutation" \o "Mutation" mutation in the adenomatous polyposis coli (APC) gene. The APC gene is a tumor suppressor gene that regulates cell adhesion, cell migration, and apoptosis in the colorectal epithelium.

Discuss Genetic Factors That Increase the Risk of Developing Colon

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