What Is the Difference Between Genotoxic Carcinogens and Cell Proliferation

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The Answer is A genotoxic agent such as a metal or its activated metabolite modifies DNA in some form that can be found by adduct formation, mutations, etc. A cell proliferation agent such a TCDD changes expression of DNA by binding to a receptor such as the Ah (or estrogenic agents bind to the ER receptors) and cause cell proliferation. This does not initiate cancer but provides mitogenic influences that promote cancer and can increase the mutation rate based on the increased rate of growth of cells (dysplasias).

What Is the Difference Between Genotoxic Carcinogens and Cell Proliferation

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