How Is G Protein-Mediated Signaling Terminated

question 19

Multiple Choice

How is G protein-mediated signaling terminated?

• A) Desensitization of the G protein-coupled receptor terminates the signaling previously initiated by active G proteins.
• B) Hydrolysis of GDP to GTP by the endogenous GTPase activity of the α-subunit leads to reassociation of the αβγ-complex, terminating the response.
• C) Exchange of GDP for GTP by the endogenous GTPase activity of the α-subunit leads to reassociation of the αβγ-complex, terminating the response.
• D) Exchange of GTP for GDP by the endogenous GTPase activity of the α-subunit leads to reassociation of the αβγ-complex, terminating the response.
• E) Hydrolysis of GTP to GDP by the endogenous GTPase activity of the α-subunit leads to reassociation of the αβγ-complex, terminating the response.

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