If You Record EPSCs with a Patch Electrode from an Interneuron

question 17

Multiple Choice

If you record EPSCs with a patch electrode from an interneuron in the
CA1 region of a rat hippocampal slice preparation and hold the postsynaptic membrane potential at -80 mV, why is the response not sensitive to blockers of NMDA receptors?

• A) There are no NMDA receptors at these synapses.
• B) At -80 mV, AMPA receptors are blocked by magnesium.
• C) At -80 mV, NMDA receptors do not bind glutamate.
• D) At -80 mV, NMDA receptors are blocked by magnesium.
• E) At -80 mV, NMDA receptors do not bind glycine or D-serine.

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