How Do Developmental Changes in Chloride Transporter Expression Affect GABAergic

question 54

Multiple Choice

How do developmental changes in chloride transporter expression affect GABAergic transmission?

• A) The developmental switch from NKCC1 to KCC2 allows GABA to become depolarizing.
• B) Changes in chloride transporter expression do not alter GABAergic transmission.
• C) In the immature brain, GABA transporters can transport both glutamate and GABA. The delayed expression of KCC2 promotes the substrate specificity of GABA transporters.
• D) Developmental changes in chloride transporters allow GABAergic transmission to have faster kinetics.
• E) The delayed expression of KCC2 allows GABA to evoke membrane hyperpolarization in the mature, not the immature brain.

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