What Is Thought to Be the Functional Significance of Charged

question 41

Multiple Choice

What is thought to be the functional significance of charged amino acids along the S4 helix of the voltage-gated sodium channel?

• A) They form the basis for sodium selectivity of the channel.
• B) They provide a mechanism for inactivation.
• C) They attract the negative charges of nearby channel subunits, forming a functional protein.
• D) They form the pore of the channel.
• E) They provide the gating mechanism for channel opening.

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