In the Rotational Model of Sodium Channel Activation, What Happens

question 29

Multiple Choice

In the rotational model of sodium channel activation, what happens when the membrane is depolarized?

• A) An activation "gate" on the N-terminus of the protein swings open, allowing ions to move.
• B) A short loop between domains III and IV swings open to allow sodium into the cell.
• C) The S4 helices rotate, shifting the position of the S6 helices to open the ion pore.
• D) A group of negatively-charged amino acids along the C-terminus rotate to open the ion pore.
• E) A short loop between S4 and S5 swings open to allow sodium into the cell.

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