With Respect to the Structure and Function of NAChRs, Cysteine

question 31

Multiple Choice

With respect to the structure and function of nAChRs, cysteine scanning

• A) provided binding sites for tritiated chlorpromazine in the M2 helix.
• B) refers to scanning for radioactivity of tritiated chlorpromazine after it reacts with cysteines in the M2 helix.
• C) provided novel binding sites for QX222 in the open channel compared to existing QX222 biding sites in the native receptor.
• D) revealed that amino acids at 2′, 3′, 6′, 8′, 9′, 10′, 13′, and 16′ lined the pore-forming side of the M2 helix.
• E) revealed that amino acids at 2′, 6′, and 9′ lined the pore-forming side of the M2 helix.

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