ACh, the Ligand, Only Binds to at -Subunits, Which Are

question 49

Multiple Choice

ACh, the ligand, only binds to at -subunits, which are 2 of the 5 subunits that comprise a nAChR yet conformational changes occur throughout its tertiary and quaternary structure. Why?

• A) Ligands span between αγ and αγ-subunits so in fact 4 of the 5 subunits are affected.
• B) Subunits interact via amino acid chains connecting their intramembrane regions, so movement in one subunit influences the others too.
• C) β-subunits drive movement for all other subunits exclusively via M2-M3 connecting loops.
• D) Via subunits tilting away from the axis of the receptor.
• E) Regardless of how many ligands bind, all subunits have M2 helices that move within the membrane.

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Definitions:

Self-Fulfilling Prophecy

A prediction that directly or indirectly causes itself to become true due to positive feedback between belief and behavior.

Perceptual Defense

The process by which individuals protect themselves from being emotionally disturbed or threatened by denying or distorting reality.

Stereotyping

The act of categorizing individuals or groups into certain characteristics or behaviors without acknowledging individual differences.

Halo Effect

A cognitive bias in which an individual's overall positive or negative impression of a person, brand, or product influences their feelings and thoughts about that entity's specific traits.