Visualization of B-Cell Traffic Between the Light and Dark Zones

question 7

Multiple Choice

Visualization of B-cell traffic between the light and dark zones of the germinal center has shown that they migrate far less than had been predicted.This demonstrates that

• A)the traditional model of trafficking is inaccurate.
• B)the rate of hypermutation and selection does not require extensive movement.
• C)only brief contacts by the B cells with helper T cells are needed.
• D)both the traditional model of trafficking is inaccurate and only brief contacts by the B cells with helper T cells are needed.
• E)both the rate of hypermutation and selection does not require extensive movement and only brief contacts by the B cells with helper T cells are needed.

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Definitions:

Coefficient Of Determination

The coefficient of determination, often denoted as R^2, is a statistic used in the context of statistical models whose main purpose is to provide a measure of how well observed outcomes are replicated by the model, based on the proportion of total variation of outcomes explained by the model.

Pearson Coefficient

A measure of the linear correlation between two variables X and Y, giving a value between -1 and 1.

Linear Relationship

A type of association where the change in a variable is consistent with the change in another variable, represented by a straight line on a graph.

Coefficient Of Determination

A measure used in statistical analysis that assesses how well a model explains and predicts future outcomes, typically represented as R-squared.