How Do Self-Antigens That Are Specific to Tissues Away from the Thymus

question 34

Multiple Choice

How do self-antigens that are specific to tissues away from the thymus (like insulin or keratin for example) get in the thymus so that developing T cells that react to them can be deleted?

• A)Dendritic cells pick them up in the periphery and carry them to the thymus.
• B)Specialized macrophages in the thymus filter the bloodstream and present antigens found there to developing T cells.
• C)A transcription factor, AIRE, is expressed in thymic medullary epithelial cells, which allows these cells to express proteins normally found in other tissues.
• D)They do not get to the thymus, all tissue-specific T cells are deleted in the periphery.
• E)There are special chaperone proteins that bind to peripheral proteins and carry them to the thymus.

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