Which of the Following Accounts for Allelic Exclusion in Rearrangement

question 11

Multiple Choice

Which of the following accounts for allelic exclusion in rearrangement within the IgH locus?

• A)Rearrangement only occurs on one homolog at a time, and once one homolog has successfully rearranged, the other is methylated to produce heterochromatin.
• B)Rearrangement is regulated by VpreB and ? 5, which are themselves only expressed at specific times during IgH rearrangement
• C)Both homologs rearrange simultaneously, undergoing multiple V-J rearrangements until a productive one occurs.
• D)All of the answers promote allelic exclusion in IgH.
• E)None of the answers are correct; allelic exclusion does not occur in IgH.

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