Indicate the Correct Sequence of Events in the Maturation of B

question 68

Multiple Choice

Indicate the correct sequence of events in the maturation of B and T lymphocytes.
1) Immature T cells in thymus and immature B cells in bone marrow undergo rapid mitosis under the influence of specific cytokines
2) Segments of genes that produce lymphocyte receptors are spliced and rearranged to produce almost 10¹⁸ different receptors.
3) Cells failing to produce a functional receptor are eliminated via apoptosis
4) Antigen receptors on immature T and B cells are screened during positive selection so that only useful receptors are generated.
5) After passing positive selection, T and B cells complete maturation process and start their patrol of the body for the presence of pathogens.

• A) 1, 2, 3, 4, 5
• B) 5, 4, 3, 2, 1
• C) 1, 2, 4, 3, 5
• D) 1, 4, 3, 2, 5

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Definitions:

Axon Diameter

Refers to the width of an axon, which influences the speed of nerve impulse conduction, with larger diameters allowing faster conduction.

Neurotransmitters

Chemicals that transmit signals across a synapse from one neuron to another in the nervous system.

Retrograde Signals

Molecular signals that travel from the postsynaptic neuron back to the presynaptic neuron, modulating neurotransmission.

Patch Clamp Technique

A method that allows researchers to study the ion channels of a tiny patch of membrane by tightly sealing a micropipette to the patch and measuring the flow of ions through the channels.