How Do Autoimmune Diseases Like Rheumatoid Arthritis, Type I Diabetes

question 55

Multiple Choice

How do autoimmune diseases like rheumatoid arthritis, Type I diabetes and Multiple Sclerosis develop?

• A) During maturation, negative selection fails to eliminate Class II MCH phagocytes with autoreactive receptors at checkpoint 1.
• B) During maturation, negative selection fails to eliminate lymphocytes with autoreactive receptors at checkpoint 2.
• C) There is an error during clonal expansion that generates an over-abundance of non-specific lymphocytes.
• D) During clonal deletion, the T_REG cells that suppress the development of autoimmune diseases are accidentally eliminated.

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Definitions:

Content Validity

The extent to which a test measures all aspects of the concept or construct it is intended to assess.

Internal Consistency Validity

A measure of whether items on a test are all assessing the same construct.

Interrater

An assessment of the degree to which different raters or observers give consistent estimates or judgments of the same phenomenon.

Parallel Forms

A method of reliability testing in which different versions of a test are administered to the same individuals at different times to measure consistency between the forms.