Indicate the Correct Order of Events in the Alternative Complement

question 37

Multiple Choice

Indicate the correct order of events in the alternative complement pathway.
1-C5b binds with C6, C7 and C8 forming a complex on the pathogen membrane
2-Properdin binds C3b and Bb to form C3 convertase
3-Factor D cleaves Factor B allowing Bb to bind C3b on pathogen surface
4-Pore formed by MAC triggers osmotic cell lysis
5-C3 convertase activity generates C5 convertase

• A) 3, 2, 1, 4, 6, 5
• B) 1, 2, 3, 4, 5
• C) 1, 3, 5, 6, 4, 2
• D) 2, 3, 1, 4, 6, 5

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