Examples of Enzymatic Modification of an Antimicrobial Agent's Structure or an Antimicrobial

question 37

Multiple Choice

Examples of enzymatic modification of an antimicrobial agent's structure or an antimicrobial agent's target include ________. (Select all that apply)

• A) methylization of the 38S rRNA that prevents antimicrobial agents from binding to inhibitory site on the bacterial ribosome
• B) expression of PBP2A that prevents beta-lactam antibiotics from binding to the penicillin binding protein and shutting down enzymatic production of peptidoglycan
• C) production of beta-lactamase that degrades the beta-lactam ring and prevents the antibacterial agent from binding to the penicillin binding protein
• D) production of chloramphenicol acetyl transferase, an enzyme that chemically modifies and inactivates chloramphenicol

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