Nucleoside Analogs Inhibit Nucleic Acid Polymerization by ________

question 111

Multiple Choice

Nucleoside analogs inhibit nucleic acid polymerization by ________. (Select all that apply)

• A) acting as terminators of synthesis after being incorporated into nucleic acid of host cell
• B) having a structure where the 3' hydroxyl group on the sugar of the nucleoside or nucleotide is deleted or modified
• C) after inclusion into growing DNA chain, the nucleotide analog blocks linkage of the next nucleotide
• D) having a greater affinity for viral polymerases than for human ones thus producing selective toxicity at therapeutic concentrations