Hemophilia Is a Genetic Disease That Has Plagued the Royal

question 50

Multiple Choice

Hemophilia is a genetic disease that has plagued the royal houses of Europe. The disease allele is recessive and X-linked. Queen Victoria was a carrier, and her granddaughter Alexandra married Nicholas II, the last czar of imperial Russia. Alexandra was a carrier for hemophilia; Nicholas was normal. Their son, Alexis, was afflicted with the disease. Alexis and his four sisters were killed in 1917. What genetic traits were possible for the four sisters?

• A) None of the four sisters carried the hemophilia allele.
• B) At least one of the sisters was a carrier of the allele.
• C) All four sisters were carriers of the hemophilia allele.
• D) At least one of the sisters had hemophilia like Alexis.

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