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The period that can be considered a "proof of concept" time was the:
Thrombus
A blood clot that forms within a blood vessel and remains there, which can obstruct blood flow.
Embolus
A blood clot, air bubble, piece of fatty deposit, or other object that has been carried in the bloodstream to lodge in a vessel and cause an embolism.
Prostacyclin
A potent vasodilator and inhibitor of platelet aggregation produced by the endothelial cells of blood vessels.
Fibrinogen
A soluble plasma protein that is converted into fibrin during blood clotting, playing a critical role in wound healing.
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