The Key Difference Between the First and Second Generation Antihistamines

question 16

Multiple Choice

The key difference between the first and second generation antihistamines is that:

• A) with second generation antihistamines, lower dosages are required for the same therapeutic effect.
• B) second generation medications have more undesirable side effects.
• C) the first generation antihistamines are more lipophilic and therefore cross the blood-brain barrier (BBB) causing central nervous system effects.
• D) the first generation antihistamines are more lipophobic and therefore cross the blood-brain barrier (BBB) causing central nervous system effects.