Loss of Heterozygosity, Structural Rearrangements, or Point Mutations of the Retinoblastoma

question 6

Multiple Choice

Loss of heterozygosity, structural rearrangements, or point mutations of the retinoblastoma tumor suppressor gene (RB) are found in 60%-70% of all sporadic bone tumors. Which of the following is the best classification for this tumor?

• A) Osteosarcoma
• B) Osteoblastoma
• C) Osteoid osteoma
• D) Chondrosarcoma
• E) Ewing sarcoma

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Definitions:

Oceanic Plateau

A large, flat, elevated region in the ocean basin, often composed of thickened crust that rises above the surrounding seafloor.

Fracture Zone

A linear zone of irregular topography on the ocean floor characterized by fractures and faults due to plate movements.

Linear Island Chain

A series of islands arranged in a straight line, formed by geological processes such as volcanic activity along a marine ridge.

Island Arc

A curved chain of volcanic islands located at a tectonic plate boundary, over a subduction zone.