Basal Cell Carcinoma of the Skin Often Contains Mutations of the P53

question 3

Multiple Choice

Basal cell carcinoma of the skin often contains mutations of the p53 gene and the gene called PTCH (mutated in congenital nevoid basal cell carcinoma syndrome) . These mutations are most likely the result of action of which of the following?

• A) Epidermal growth factor
• B) G-protein signal transduction system
• C) Chemical carcinogens from the environment
• D) Ultraviolet light
• E) Cosmic radiation

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