Naive CD8⁺ T Cells Require Signals in Addition to T

question 10

Multiple Choice

Naive CD8⁺ T cells require signals in addition to T cell receptor recognition of peptide-MHC to become activated and differentiate into cytolytic T cells. These signals are called costimulatory signals and are provided by professional antigen-presenting cells (APCs) , such as dendritic cells. If a virus infects epithelial cells in the respiratory tract but does not infect professional APCs, what process ensures that naive T cells specific for viral antigens will become activated?

• A)Cross-reactivity, whereby the naive CD8⁺ T cell recognizes a self antigen that is structurally similar to a viral antigen presented by dendritic cells
• B)Crossover, whereby part of the viral genome is exchanged with part of one chromosome of the host
• C)Crosstalk, whereby signals generated by the virus binding to class I MHC molecules intersect with T cell receptor signaling pathways
• D)Cross-presentation, whereby infected epithelial cells are captured by dendritic cells, and the viral proteins originally synthesized in the epithelial cells are processed and presented in association with class I MHC molecules on the dendritic cell
• E)Cross-dressing, whereby viral infection of the epithelial cell stimulates the expression of surface molecules that are typically found only on dendritic cells

---

Definitions:

Ludus

In John Lee’s typology of love, playful love.

Mania

In John Lee’s typology of love, obsessive love.

Commitment

A determination, based on conscious choice, to continue a relationship or a marriage.

"I-Thou" Relationship

A concept from philosophy that emphasizes mutual respect, recognition, and valuing the other person as a distinct and valuable being, beyond merely instrumental or utilitarian considerations.