LFA-1 Is an Integrin That Promotes T Cell Activation by Which

question 16

Multiple Choice

LFA-1 is an integrin that promotes T cell activation by which one of the following mechanisms?

• A)Binds to the α3 domain of class I MHC molecules, mediating high avidity between T cells and antigen-presenting cells (APCs)
• B)Binds to B7-1 or B7-2 on the surface of APCs, mediating "signal 2"
• C)Binds to GlyCAM-1 on high endothelial venules of lymph nodes, mediating rolling of T cells on endothelium
• D)Binds to ICAM-1 on the surface of a variety of cells, mediating firm adhesion between T cells and APCs or endothelial cells
• E)Binds to VCAM-1 on the surface of cytokine-activated endothelial cells, mediating homing of T cells to peripheral sites of inflammation

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Definitions:

Anuria

A medical condition characterized by the failure of the kidneys to produce urine.

Hematuria

The presence of blood in urine, which can indicate urinary tract infections, kidney stones, or more serious conditions like cancer.

Urine

A liquid by-product of metabolism in the body, expelled through the urinary system; it consists of urea, water, salts, and other waste compounds.

Urine Specimen

A sample of urine collected for diagnostic purposes to test for various diseases, conditions, or drug usage.