The Strength of Integrin-Dependent Binding of T Cells to Antigen-Presenting

question 5

Multiple Choice

The strength of integrin-dependent binding of T cells to antigen-presenting cells (APCs) may be rapidly increased by which one of the following mechanisms?

• A)Integrin clustering and increased integrin affinity are induced by chemokines and antigen recognition.
• B)Integrins stored in cytoplasmic organelles are mobilized to the T cell surface in response to TCR-mediated signals.
• C)Integrin gene transcription is enhanced by chemokine-generated signals.
• D)The affinity of integrin ligands on APCs is increased in response to chemokines.
• E)Integrin ligands stored in cytoplasmic granules in the APCs are mobilized to the cell surface in response to CD40-CD40 ligand interaction.

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