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A 7-month-old boy, the only child of second-degree cousins, saw a pediatrician for immunologic evaluation after developing Pneumocystis carinii pneumonia. Serum IgG, IgM, and IgA levels were normal. Blood cell count showed 10,600 leukocytes/mm³ and 80% lymphocytes; 90% of the lymphocytes were TCR αβ⁺ CD4⁺. In vitro lymphocyte-proliferative responses to PHA and anti-CD3 were absent, and the pattern of tyrosine-phosphorylated cytoplasmic proteins after anti-CD3 treatment of the T cells was distinctly abnormal. This boy most likely carries homozygous mutations in the gene encoding which one of the following proteins?
Scarcity
The state of being in short supply; a situation where resources are insufficient to satisfy the needs or wants of individuals or societies.
Reactance
A psychological response that occurs when people feel their freedom to choose is being limited, prompting a motivation to regain that freedom.
Restricted Choices
A situation characterized by limited options or alternatives available for selection.
Ethical Resistance
The act of opposing actions or decisions that violate moral principles or codes of conduct.
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