Which of the Following Mechanisms Contributes to the Change from B

question 8

Multiple Choice

Which of the following mechanisms contributes to the change from B cell production of membrane Ig to secreted Ig?

• A)V(D)J recombinase-mediated deletion of the exon encoding the transmembrane domain
• B)Alternative processing of primary RNA transcripts to remove the transmembrane domain and include a secretory tail piece
• C)Increased vesicular exocytosis of intracellular stores of the secretory form of Ig
• D)Switch recombinase-mediated recombination of the heavy chain locus to juxtapose the V(D)J segment with the exon encoding a secretory tail piece
• E)Up-regulation of ectoenzymes that proteolytically cleave membrane Ig heavy chains just proximal to the membrane

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Definitions:

Chemical

A chemical is any basic substance that is used or produced in any chemical process, characterized by having a specific set of properties and composition.

Empiricist

An empiricist is someone who believes that knowledge comes primarily from sensory experience and observation.

Proximal Stimulus

The physical energy from a stimulus as it directly interacts with sensory receptors, such as the pattern of light hitting the retina.

Distal Stimuli

External objects and events in the environment that provide the basis for the perception of stimuli.