Suppose Drug a and Drug B Are to Be Separated

question 2

Multiple Choice

Suppose drug A and drug B are to be separated by anion-exchange chromatography.Drug A is an acid with a pKₐ of 8.0, and drug B is an acid with a pKₐ of 4.0.Following the proper steps to place the mixture of drugs onto the anion-exchange phase, the pH of the mobile phase should be adjusted to ______ to elute drug A only.Then the pH of the mobile phase should be adjusted to _____ to elute drug B from the stationary phase.

• A)4.0, 8.0
• B)8.0, 4.0
• C)10.0, 6.0
• D)6.0, 2.0

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