Select the Correct Sequence of Steps That Must Occur for the Development

question 3

Multiple Choice

Select the correct sequence of steps that must occur for the development of colorectal cancer.
1) Mutations of tumor suppressor gene 53 and deletions on chromosome 18q coincide with transition to malignancy.
2) Mutations in the adenomatous polyposis coli (AOC) tumor-suppressor gene occur early in the development of polyps.
3) Oncogenic K-ras mutations arise during the adenomatous stage.

• A)1, 2, 3
• B)2, 3, 1
• C)3, 1, 2
• D)2, 1, 3

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