Phosphorylation of Tyr⁵²⁷ in the SH₂ Domain of Protein Tyrosine

question 28

Multiple Choice

Phosphorylation of Tyr⁵²⁷ in the SH₂ domain of protein tyrosine kinase pp60ᶜ⁻ˢʳᶜ inhibits tyrosine kinase activity.By which of the following mechanisms does it do this?

• A)by moving an "activation loop" away from the active site
• B)by moving an "activation loop" into the active site
• C)by phosphorylating an "activation loop"
• D)by covalent linkage to an "activation loop"

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