Hydrogen Is Often Abstracted from Substrates as H⁺; However,electronegative Fluorine

question 16

Multiple Choice

Hydrogen is often abstracted from substrates as H⁺; however,electronegative fluorine cannot be readily eliminated.Which of the following explains how enzyme inhibitors be fashioned to overcome this?

• A)by replacing H with F-F at positions where catalysis involves H removal as H⁺
• B)by replacing H with F- at positions where catalysis involves H removal as H⁺
• C)by replacing H with F+ at positions where catalysis involves H removal as H⁺
• D)by replacing H with F at positions where catalysis involves H removal as H⁺

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