How Does the "Hole in the T Cell Repertoire" Model

question 9

Multiple Choice

How does the "hole in the T cell repertoire" model explain why some individuals may fail to respond to an antigen?

• A) MHC class II molecules differ in their ability to bind and process antigen.
• B) The TCR is lacking appropriate accessory molecules to fully transduce signals.
• C) Some individuals lack a lymphocyte with a TCR that recognizes a specific antigen.
• D) Antigen is inappropriately presented on MHC class I molecules rather than class II molecules.

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