The Authors State: "In This Study,we Report That,in the Absence of Neuronal Activity,MeCP2

question 14

Multiple Choice

The authors state:
"In this study,we report that,in the absence of neuronal activity,MeCP2 binds specifically to BDNF promoter III and functions as a negative regulator of BDNF expression.In response to neuronal activity-dependent calcium influx into neurons,MeCP2 becomes phosphorylated and is released from the BDNF promoter,thereby permitting BDNF promoter III-dependent transcription." Reading this statement in isolation,it would be easy to have the impression that MeCP2 works as a negatively acting transcription factor.However,based on the summary of the paper provided above,MeCP2 acts as a _____.

• A)gene-specific regulator of chromatin condensation
• B)positively acting transcription factor
• C)splicing regulator
• D)translational regulator

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