A Woman Whose Father Does Not Have Hemophilia Gives Birth

question 22

Multiple Choice

A woman whose father does not have hemophilia gives birth to a son with classic hemophilia. This woman is found to have only 15% of the normal amount of clotting factor VIII (the clotting factor males with hemophilia are missing) and does have abnormal blood-clotting issues. Which phenomenon or factor is most likely responsible for her abnormal clotting factor expression?

• A)The X chromosome most commonly inactivated in her bone marrow is paternally derived.
• B)The X chromosome most commonly inactivated in her bone marrow is maternally derived.
• C)This woman is demonstrating reduced penetrance of an X-linked-recessive disorder.
• D)This woman is demonstrating full penetrance of an X-linked-recessive disorder.

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Definitions:

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