In Fragile X Syndrome, Only Noncoding Regions Within the Gene

question 2

Multiple Choice

In fragile X syndrome, only noncoding regions within the gene for a protein that directs and maintains brain development are heavily methylated, resulting indecreasedcognitive ability and behavioral problems. What is the most likely mechanism of this abnormal expression?

• A)Increased microRNA molecules reducing the synthesis of the gene product
• B)Failure of the methylated regions to undergo translation
• C)Suppression of the "splicing out" action for introns
• D)Suppression of promoter function

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