What Is the Best Explanation for a Person Whose Karyotype

question 5

Multiple Choice

What is the best explanation for a person whose karyotype from blood cells shows nearly all cells to have trisomy 21 to have 10 clinical manifestations of Downsyndromeand an above-average intelligence?

• A)The trisomy was a result of nondisjunction of paternal gametes instead of maternal gametes.
• B)The person has pseudo-Down syndrome, in which environmental conditions caused the person to have development that mimics only the physical manifestations.
• C)The person has genomic imprinting, in which the paternal number 21 chromosome is not expressed, and both maternally derived number 21 chromosomes are expressed.
• D)The person has mosaicism of trisomy 21, with blood cells having a high proportion and neurons having a low proportion of cells, with three number 21 chromosomes.

---

Definitions:

Beta Oxidation

The metabolic process by which fatty acid molecules are broken down in the mitochondria to generate acetyl-CoA, NADH, and FADH2.

Electron Transport Chain

A sequence of complexes involved in moving electrons from donors to acceptors through redox processes, while simultaneously moving protons across a membrane to produce ATP.

Citric Acid Cycle

A series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins into carbon dioxide and chemical energy.

ATP Generation

The process by which adenosine triphosphate (ATP), the cell's energy currency, is produced, commonly through cellular respiration or photosynthesis.