You Are Caring for a Child with Acute Lymphoblastic Leukemia

question 6

Multiple Choice

You are caring for a child with acute lymphoblastic leukemia. She has been genotyped and is homozygous for a TPMT polymorphism, producing very little of the enzymeneeded for this drug's metabolism. How would you expect this to affect dosing of the drug 6-mercaptopurine?

• A)This child should receive only a small fraction of the standard dose.
• B)This child should receive the drug intravenously rather than orally.
• C)This child should receive higher doses than the standard dose.
• D)This child should receive the standard dose.

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Definitions:

Eating Behaviour

Refers to the patterns, motivations, and factors influencing what, when, and how much an individual eats.

Modulation of Pain

The process by which the perception of pain is adjusted or altered by various factors, such as psychological or physiological interventions.

Body's Response

The way an organism's systems react to internal or external stimuli, which can include physiological changes or behaviors.

Efferent Nerve Fibres

Nerves that carry impulses away from the central nervous system to effectors, such as muscles or glands, facilitating action.