Inhibitors of Enzymes Can Be Either Reversible or Irreversible

question 8

Essay

Inhibitors of enzymes can be either reversible or irreversible.The most common reversible inhibitors are competitive or noncompetitive.Based on what you know about enzyme inhibitors,can you determine the type of inhibition discussed in these examples?
a.Diisopropyl fluorophosphate binds to acetylcholinesterase and permanently inactivates the enzyme.Paralysis results.
b.An inhibitor binds to the active site of an enzyme but disassociates and leaves the enzyme active.
c.A toxin binds to an enzyme.The enzyme then binds the substrate.No product is produced.The toxin may disassociate and allow for product formation.
d.Vitamin K is a coenzyme involved in blood clotting.An anticoagulant drug binds at the site of vitamin K and prevents clotting.Clotting resumes after the drug has been discontinued.
e.Aspirin binds to prostaglandin synthetase and permanently stops its ability to produce prostaglandin.

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