The Molecule 1,3-Bisphosphoglycerate Can Be Converted to 3-Phosphoenolpyruvate Two Ways

question 74

Multiple Choice

The molecule 1,3-bisphosphoglycerate can be converted to 3-phosphoenolpyruvate two ways.One way is catalyzed by the glycolytic pathway enzyme phosphoglycerate kinase.The other route is a two step reaction sequence that uses the enzymes bisphosphoglycerate mutase and 2,3-bisphosphoglycerate phosphatase.The intermediate product of the two-step sequence is 2,3-BPG which is an allosteric inhibitor of hemoglobin.What disadvantage would there be if the glycolytic pathway only used the two-step reaction sequence?

• A)The step catalyzed by phosphoglycerate kinase is one of the ATP producing steps of glycolysis.Using only the two-step reaction sequence would reduce the number of ATP's produced.
• B)There is no disadvantage to the two-step sequence other than having to use more than one enzyme.
• C)The molecule 2,3-BPG is also a potent inhibitor of PFK-1.Even transient production of 2,3-BPG will significantly slow glycolysis.
• D)Too much 2,3-BPG would be produced which would cause clumping of red blood cells.

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